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7 Epic U.S. Road Trips by Theme

July 30, 2025

8 -min read

The fastest way across America? Take a plane. The most scenic? Try a train. But if you want the journey to be just as memorable as the destination, nothing beats the open road.

Road trips let you discover America at your own pace — windows down, music up — stopping at hidden gems, chatting with locals at roadside diners, and experiencing those “wow” moments you can’t plan for. 

We’ve designed seven epic routes that match your interests, whether you’re drawn to musical history, incredible food, or stunning natural landscapes. Each trip reveals what makes different corners of America truly special.

Music Lovers: The Blues Highway

Trip: Memphis to New Orleans | Route: Tennessee → Mississippi → Louisiana

Experience the birthplace of American music while connecting with local musicians and learning how a blend of cultures created these iconic sounds.

Stop #1: Memphis, Tennessee
Known as the hometown of blues, Memphis is also home to iconic landmarks like Beale Street, Graceland (Elvis Presley’s mansion), and Sun Studio — the recording studio where many music legends got their start.

Photo by BruceEmmerling.

Stop #2: Clarksdale, Mississippi
Visit the iconic Delta Blues Museum, which celebrates the rich legacy of blues music and the Ground Zero Blues Club —a juke joint with authentic, original performances.

Photo by Hank Word.

Stop #3: Vicksburg, Mississippi
Vicksburg is a historic city known for its important Civil War battlefield. It offers blues venues along the riverfront that carry the sounds of Mississippi’s musical heritage.

Photo by Kodiak.

Stop #4: New Orleans
The French Quarter in New Orleans is a lively, historic district known for its vibrant jazz clubs that spill music into the streets night and day. At its heart is Preservation Hall, an intimate, no-frills venue dedicated to keeping traditional New Orleans jazz alive through raw, soulful performances by master musicians.

Photo by i_am_curioski.

Best time to go: Fall (October-November) when temperatures are moderate and there are more intimate music events or Spring (March-May) when the New Orleans Jazz and Heritage Festival takes place amid the blooming wildflowers.

Food Enthusiasts: The Southern Comfort Trail

Trip: Nashville to Charleston | Route: Tennessee → Georgia → South Carolina 

Learn cooking techniques from local chefs and understand how different cultures shaped regional American cuisine.

Stop #1: Nashville, Tennessee
Nashville is full of bold flavors and Southern comfort. From authentic hot chicken and smoky BBQ that falls off the bone to sides like mac and cheese or fried okra, the city’s food is as unforgettable as its music. Then dance it all off at Honky Tonk Central — Nashville’s largest honky tonk—where live country music and high-energy dancing keep the party going all night!

Photo by T.Tseng.

Stop #2: Atlanta, Georgia
Atlanta blends Southern tradition with modern appetites. Foodies can explore everything from classic soul food and fried chicken to international food markets and farm-to-table dining — all while enjoying the city’s rich civil rights history and lively arts scene.

Photo by Gatorfan252525.

Stop #3: Savannah, Georgia
Savannah welcomes visitors with moss-draped oak trees, cobblestone streets, and coastal foods. Enjoy a rich culinary experience wrapped in Southern elegance, complete with fresh-caught shrimp and creamy grits to lowcountry boils and sweet pralines.

Photo by jpellgen.

Stop #4: Charleston, South Carolina
Charleston is a coastal city known for its unique light-colored architecture, historic markets, and lowcountry cuisine—ranging from she-crab soup and shrimp and grits to elegant farm-to-table dining.

Photo by Jo Anna Barber.

Best time to go: Fall (September-November) when temperatures are more comfortable for exploring outdoor markets and food festivals—and harvest season means the freshest ingredients at farm-to-table restaurants. 

History Buffs: The Freedom Trail Extended

Trip: Boston to Philadelphia | Route: Massachusetts → Connecticut → New York → New Jersey → Pennsylvania 

Walk in the footsteps of America’s founders while exploring how diverse communities built the nation.

Stop #1: Boston, Massachusetts
A must-visit for history buffs, Boston is where the American Revolution originated. Walk the Freedom Trail to explore landmarks like Paul Revere's House, the USS Constitution Museum (honoring the oldest commissioned warship in the world), and Old North Church (which launched Paul Revere’s ride).

Photo by Kenneth C. Zirkel.

Stop #2: New Haven, Connecticut
Home to Yale University, New Haven blends Ivy League status with deep historical roots. History enthusiasts can explore colonial-era architecture, storied libraries, and museums, while also enjoying the city’s famous New Haven-style pizza.

Photo by Gunnar Klack.

Stop #3: New York City, New York
New York City is a living museum of history, from the Statue of Liberty, symbolizing freedom to Ellis Island's immigrant stories. Visit iconic landmarks like the 9/11 Memorial, and centuries-old neighborhoods that reveal the city’s rich and diverse past.

Photo by Nadia Eimandoust.

Stop #4: Philadelphia, Pennsylvania
Philadelphia is the birthplace of American independence, where history comes alive at Independence Hall and the Liberty Bell. Learn the stories of the Founding Fathers, explore Revolutionary War sites, and walk the cobblestone streets of Old City.

Photo by National Parks Gallery.

Best time to go: Fall (September-November) when mild temperatures are perfect for walking tours, colorful trees create beautiful scenic drives between cities, and fewer tourists crowd main sites like the Statue of Liberty. 

Parking pro-tips: Parking along this route can be especially tricky. Downloading parking apps like SpotHero, ParkWhiz, or BestParking while in Boston, NYC, and Philly, can help you reserve spots in advance. When possible, park outside major cities and take public transportation in. Check signage carefully to avoid street cleaning times and parking tickets. And make sure you research your options by city ahead of time, depending on your specific itinerary.

Nature Lovers: The Pacific Coast Highway Adventure

Trip: San Francisco to Los Angeles | Route: California coastline 

Experience California’s environmental conservation efforts and learn about sustainable tourism practices.

Stop #1: San Francisco, California
San Francisco has breathtaking views for nature lovers, where the coastline meets urban charm. Explore the iconic Golden Gate Park, hike the 4-mile scenic trails of Lands End, or take a short trip to nearby Muir Woods to walk among 2,000-year-old redwood trees.

Photo by King of Hearts.

Stop #2: Monterey, California
Monterey is a paradise for nature lovers, known for its stunning 17-mile coastline drive and diverse fish population. Wander the scenic Monterey Bay Coastal Trail, visit the world-renowned Monterey Bay Aquarium, and enjoy ocean views and wildlife sightings from Point Lobos Natural Reserve.

Photo by Ian Abbott.

Stop #3: Big Sur, California
Big Sur delights nature lovers with its dramatic cliffs, towering redwood trees, and scenic views of the Pacific Ocean. Drive the iconic Highway 1, hike through gorgeous forests, and be sure to visit McWay Falls (80-foot waterfall drop onto the beach) and the famous Hearst Castle.

Photo by Don Graham.

Stop #4: Santa Barbara, California
Santa Barbara is a blend of pleasant Mediterranean climate, stunning beaches, and nearby mountain trails. Explore the scenic coastline, hike the foothills of the Santa Ynez Mountains, or stroll through lush botanical gardens that showcase the region’s exotic flowers.

Photo by Ian Abbott.

Stop #5: Los Angeles, California
Los Angeles surprises nature lovers with its diverse landscapes—from the sandy shores of Malibu and Venice Beach to the hiking trails of Griffith Park and the Santa Monica Mountains. LA offers endless adventures—from green city spaces to nearby deserts and canyons. And don’t forget to stop by the iconic Hollywood Hills…get that photo!

Photo by Amatullah Guyot.

Best time to go: Spring (April-June) when wildflowers are in full bloom or Fall (September-November) with clear, mild, sunny days perfect for coastal driving and outdoor activities like hiking.

Adventure Seekers: The Four Corners Circuit

Trip: Denver to Moab | Route: Colorado → Utah → Arizona → New Mexico 

Calling all adventure-seekers! Get ready to engage with Native American communities and learn about indigenous cultures while respecting sacred lands.

Stop #1: Denver, Colorado
Denver is the perfect gateway to your next adventure—via the Rocky Mountain National Park gateway, to be exact. From thrilling hikes and mountain biking to skiing and white-water rafting, Denver offers endless outdoor excitement and a lively urban scene where you can recharge after your adventures.

Photo by Scrubhiker.

Stop #2: Moab, Utah
Moab is a playground for adventure seekers, surrounded by stunning red rock landscapes and two national parks — Arches and Canyonlands. Whether you’re hiking, mountain biking, or exploring canyons, there’s something exciting to discover in every corner of Moab.

Photo by Ken Lund.

Stop #3: Monument Valley, Arizona
Monument Valley is a great place for people who love adventure. You’ll see tall red rock formations and wide desert views. Take a guided jeep tour, walk on beautiful trails, and learn about Navajo culture in one of the most amazing places in the Southwest.

Photo by Fabio Achilli.

Stop #4: Santa Fe, New Mexico
Santa Fe combines rich cultural heritage with outdoor adventure with desert landscapes and nearby mountains. Adventure seekers can hike scenic trails, explore ancient villages, and experience Native American art and culture.

Photo by John Karwoski.

Best time to go: Spring (April-May) or Fall (September-October) when it’s perfect weather for hiking, cultural events, and outdoor activities without experiencing summer’s intense desert heat or winter snows that can lead to roads closing. 

Culture Enthusiasts: The Great Lakes Art Trail

Trip: Chicago to Detroit | Route: Illinois → Indiana → Michigan 

Learn how people from different countries helped build America’s factory cities throughout the midwest, creating new art and culture at the center of the country.

Stop #1: Chicago, Illinois
Chicago has no shortage of culture, offering world-class museums, the iconic Chicago Architecture Foundation Center River Cruise, and a legendary music scene. Visit the Art Institute of Chicago, catch a jazz show in historic clubs, walk along the Chicago River Walk, and don’t forget to get a picture in front of the Bean (aka Cloud Gate) at the famous Millennium Park!

Photo by vincent desjardins.

Stop #2: Indiana Dunes, Indiana
Indiana Dunes is a hidden treasure for those who like their nature and history combined. Explore beaches along Lake Michigan, hike through diverse habitats, and visit the nearby historic towns with charming local art galleries and museums.

Photo by JoeyBLS.

Stop #3: Grand Rapids, Michigan
Grand Rapids is a cultural destination known for its colorful art scene. Culture enthusiasts can explore the renowned Frederik Meijer Gardens & Sculpture Park, visit local museums, and enjoy lively festivals that celebrate the city’s creative spirit.

Photo by Eric Prouzet.

Stop #4: Detroit, Michigan
Detroit is a city of strength and creativity, rich in music history and revived arts scenes. Culture enthusiasts can enjoy the Motown Museum and explore galleries and street art, experiencing the mix of innovation and tradition that shapes the city’s future.

Photo by Kelly Verdeck.

Best time to go: Late Spring to Early Fall (May-September) when the warm weather makes outdoor attractions like Indiana Dunes and Detroit’s street art district enjoyable. Summer also brings several cultural festivals without harsh Midwest winters that limit activities and create challenging driving conditions. 

Small-Town Explorers: The Appalachian Heritage Route

Trip: Asheville to Louisville | Route: North Carolina → Tennessee → Kentucky 

Experience authentic American small-town life and learn about Appalachian traditions passed down through generations.

Stop #1: Asheville, North Carolina
Asheville charms small-town explorers with its vibrant arts scene, historic architecture, and welcoming mountain culture. Explore the local shops downtown and then escape to nearby Blue Ridge Mountains for scenic hikes and peaceful nature spots.

Photo by Asheville Photography.

Stop #2: Great Smoky Mountains (Between Tennessee and North Carolina)
The Great Smoky Mountains offer breathtaking mountain views, historic towns, and abundant wildlife. Enjoy cozy mountain villages, scenic drives, and miles of hiking trails that reveal waterfalls, wildflowers, and Appalachian heritage.

Photo by F. D. Richards.

Stop #3: Nashville, Tennessee
Nashville invites small-town explorers to experience its warm Southern hospitality beyond the famous music scene. Discover charming neighborhoods, eateries, and cafes that make this friendly big city feel more like a welcoming small town.

Photo by Derrick Brutel.

Stop #4: Mammoth Cave, Kentucky
Mammoth Cave offers a unique adventure into the world’s longest cave system surrounded by peaceful rural charm. Visitors can take guided tours underground and then hike among the wildlife in the calm countryside.

Photo by James St. John.

Stop #5: Louisville, Kentucky
Louisville combines the charm of a small town with the energy of a big city, known for its historic neighborhoods and vibrant arts scene. Walk along the scenic Waterfront Park, enjoy friendly cafés, and visit unique shops that capture the city’s welcoming spirit.

Photo by Bill Griffin.

Best time to go: Fall (September-November) when the mild weather, mountains, and colorful leaves create the perfect scenic drive up Blue Ridge Parkway and a more comfortable experience exploring caves and other outdoor sites. This way, you’ll avoid summer humidity and road closures on higher elevations in the winter. 

Additional Planning Resources

While road trips are amazing ways to make the most of your time in the U.S., they do require a bit of preparation ahead of time. Check out these resources on driving, lodging, and more to ensure you have a smooth trip and avoid unnecessary bumps along the way.

Time to take the wheel​

As you can see, these road trips offer more than scenic routes – they’re pathways to understanding America’s cultural landscape. Each journey provides opportunities to connect with locals, experience authentic traditions, and create memories that extend far beyond typical tourist attractions. Ready to explore? Your American adventure awaits on the open road.

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Katie recently joined the InterExchange Marketing team, bringing 15 years of agency experience in copywriting and content strategy. Also a Bollywood dance educator, she’s passionate about cultural exchange as a driver of learning, connection, and growth.

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